I find there are some that just have to be talking if the instructor is talking, and the comments are usually that students perception of a relevancy to the class, yet are very distracting. I tried to briefly answer one or two questions, but eventually had to say in a nice way that we need to stay more focused on the topic at hand and if the student wished we could have a more pointed discussion outside of classtime that would hopefully answer his questions. Writing questions down is something I have not tried as yet, but I can see that slowing the problem signficiantly becuase the student that usually is asking so much is one that has a hard time paying attention to the class. One such student in my class recently had an issue with knowing what I had talked about because he was formulating the next question in his head instead of listening to the material in class. The success rate of such a student is often low because they spend so much time thinking of questions to ask that they think add to the class but in fact are distracting.